If you get vaginal bleeding after the menopause make an appointment to see your doctor as soon as possible. There's no evidence that amitriptyline affects either male or female fertility. Cannabis with amitriptyline can give you a fast heartbeat. Cannabis can also make drowsiness worse, especially if you've just started taking amitriptyline. Methadone and other opiates for example, heroin can increase the risk of severe drowsiness if you're taking amitriptyline.
Find out more the side effects of some recreational drugs on the Frank website. Amitriptyline has not been properly tested with recreational drugs. Talk to your doctor if you think you might use recreational drugs while taking amitriptyline. Page last reviewed: 9 September Next review due: 9 September Amitriptyline for depression On this page About amitriptyline for depression Key facts Who can and cannot take amitriptyline How and when to take amitriptyline for depression Side effects How to cope with side effects of amitriptyline Pregnancy and breastfeeding Cautions with other medicines Common questions about amitriptyline.
About amitriptyline for depression Amitriptyline is an antidepressant medicine. Help us improve our website Can you answer a quick question about your visit today? It works by increasing levels of a chemical called serotonin in your brain. You may start to feel better after 1 to 2 weeks but it can take 4 to 6 weeks for amitriptyline to work fully.
Side effects such as a dry mouth and constipation are common. They're usually mild and go away after a couple of weeks. It's best to take amitriptyline in the evening or before you go to bed. This is because it can make you feel sleepy. Amitriptyline can cause side effects if you stop taking it suddenly. Talk to your doctor if you want to stop taking it.
To make sure it's safe for you, check with your doctor if you: have ever had an allergic reaction to amitriptyline or any other medicine have a heart problem — amitriptyline can make some heart problems worse have a rare blood disorder called porphyria have liver problems have epilepsy or are having electroconvulsive treatment ECT — amitriptyline may increase your risk of having a fit or seizure are pregnant, trying to get pregnant or breastfeeding have glaucoma — amitriptyline can increase the pressure in your eye have thoughts about harming yourself or ending your life have problems emptying your bladder have type 1 or type 2 diabetes If you have diabetes , amitriptyline can make it more difficult to keep your blood sugar stable.
Dosage and strength Amitriptyline tablets come in different strengths of 10mg, 25mg or 50mg. The maximum dose of amitriptyline is mg per day. How to take it Amitriptyline does not usually upset your stomach, so you can take it with or without food.
What if I forget to take it? Never take 2 doses at the same time to make up for a forgotten dose. What if I take too much? Taking more than your prescribed dose of amitriptyline can: make you feel agitated make you sick vomiting cause shaking cause a fast heart rate cause fits or seizures shaking and jerking uncontrollably. Urgent advice: Contact for advice now if:.
Common side effects Keep taking the medicine but talk to your doctor or pharmacist if these common side effects bother you or do not go away: constipation dizziness dry mouth feeling sleepy, tired or weak difficulty peeing headaches Serious side effects It happens rarely, but some people have a serious side effect after taking amitriptyline. Call a doctor straight away if: your heartbeat becomes fast or irregular the whites of your eyes turn yellow, or your skin turns yellow although this may be less obvious on brown or black skin, or you have dark pee — these can be signs of a liver problem you have constant headaches, long lasting confusion or weakness, and frequent muscle cramps — together, these can be a sign of low sodium levels in your blood.
In severe cases low sodium levels can lead to a fit or seizure you have thoughts about harming yourself or ending your life you have eye pain, a change in your eyesight, or swelling or redness in or around your eye you have constipation that lasts a long time, or problems peeing which are causing stomach ache. Immediate action required: Call and ask for an ambulance if:. Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction anaphylaxis to amitriptyline.
Information: You can report any suspected side effect using the Yellow Card safety scheme. Visit Yellow Card for further information. What to do about : constipation — eat more high-fibre foods such as fresh fruit and vegetables and cereals.
Try to drink several glasses of water or other non-alcoholic drinks every day. If you can, it may also help to increase your level of exercise. Drink plenty of water or other non-alcoholic drinks. Do not stand up too quickly after you have been sitting or lying down. Do not drive until you stop feeling dizzy. Do not drive, cycle or use tools or machinery if you're feeling sleepy. Talk to your doctor if this does not help. Do not try to force the flow of urine. If you still cannot go, try again later.
Talk to your doctor urgently if you cannot pee at all. Try not to drink too much alcohol. Paracetamol and ibuprofen may help if you need pain relief.
The risk of adverse reactions is especially high in older patients with several comorbidities. Amitriptyline is a type of TCA.
It causes anti-histaminic and anti-cholinergic side effects. In this study, the most common side effects were drowsiness, dry mouth, and constipation, which are similar to those reported in other studies. Older patients become sensitive to medication probably because of the reduction in numbers of neurons and receptors, age-related change in blood-brain barrier. In this study, we demonstrated that the therapeutic dose of amitriptyline for older patients is lower than that for younger patients.
With careful side effect monitoring and dose adjustment, low-dose amitriptyline seemed to be effective in older BMS patients. Severity and characteristics of pain might not change according to the age of patients. This means that the target symptoms were similar in all groups. The socioeconomic burden of chronic pain is huge for individuals and the society. One of the advantages of amitriptyline is its low cost. However, amitriptyline was not included in their analysis. Therefore, the therapeutic dose of amitriptyline for older BMS patients may be lower than that for younger patients.
The world population is ageing and the number of older BMS patients is increasing. This study suggests that older BMS patients can experience clinical improvements with a low dose of amitriptyline compared to younger patients. Low-dose amitriptyline may be tolerable and effective in older patients with BMS.
The elderly patients are vulnerable to medication and at higher risk for side effects. Further research is necessary to investigate the long-term safety and outcome of amitriptyline for BMS treatment in older patients. Careful evaluation of patients, careful prescription of drugs, and careful monitoring are critical for the treatment of older BMS patients. Our study has some limitations. Because of the short-term study design, we could not assess the long-term side effects of amitriptyline.
Additionally, we did not include a control group in this study. Moreover, the side effects were not systematically monitored and recorded, which may have led to an underestimation of the occurrence rate of these side effects. Regarding cognitive impairment, we assessed cognitive ability based on our clinical impression and by using the MMSE. Cognitive impairment might be assessed differently by a specialist. Regarding the dosage of amitriptyline, there may be a bias in deciding the dose of amitriptyline because each attending dentist might have a preference in prescribing a smaller dose for older patients to avoid side effects.
This study suggests that the therapeutic dose of amitriptyline may be lower for older BMS patients than for younger patients. The dataset supporting the conclusions of this article is available in the Department of Psychosomatic Dentistry, Graduate School of Tokyo Medical and Dental University. The roles of the authors were: AT confirmed dental diagnosis. All authors contributed to data analysis, drafting and revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.
The authors report no other conflicts of interest in this work. National Center for Biotechnology Information , U. Journal List Neuropsychiatr Dis Treat v.
Neuropsychiatr Dis Treat. Published online Dec Author information Article notes Copyright and License information Disclaimer. Received Oct 22; Accepted Dec This work is published and licensed by Dove Medical Press Limited.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
For permission for commercial use of this work, please see paragraphs 4. This article has been cited by other articles in PMC. Practice guideline for the treatment of patients with major depressive disorder 3rd ; Abstract Objective To assess the therapeutic dose and safety of amitriptyline and the outcome following treatment with amitriptyline among older patients with burning mouth syndrome BMS.
Results Thirty-two patients 17 in group 1, 10 in group 2, and 5 in group 3 stopped taking amitriptyline due to side effects. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. Other side effects not listed may also occur in some patients.
If you notice any other effects, check with your healthcare professional. If they do not, and this is a problem for you, go back to your doctor to see if there's another medicine you can try. If you're a woman and you get vaginal bleeding after the menopause , make an appointment to see your doctor as soon as possible.
There is no clear evidence that amitriptyline affects either male or female fertility. Cannabis with amitriptyline can make you feel very sleepy, especially if you've just started taking amitriptyline. Cannabis with amitriptyline can also give you a fast heartbeat.
Amitriptyline has not been properly tested with recreational drugs. Talk to your doctor if you think you might use recreational drugs while taking amitriptyline.
Page last reviewed: 16 September Next review due: 16 September Amitriptyline for pain and migraine On this page About amitriptyline for pain and migraine Key facts Who can and cannot take amitriptyline How and when to take amitriptyline Side effects How to cope with side effects of amitriptyline Pregnancy and breastfeeding Cautions with other medicines Common questions about amitriptyline.
About amitriptyline for pain and migraine Amitriptyline is a medicine used for treating pain. You can take it: to treat nerve pain neuralgia and back pain to help prevent migraine attacks Amitriptyline is available on prescription. Amitriptyline is also used to treat depression. Help us improve our website Can you answer a quick question about your visit today? It's best to take your amitriptyline in the evening or before you go to bed. This is because it can make you feel sleepy. You may start to feel better after 1 or 2 weeks, but it can take 6 weeks for amitriptyline to work as a painkiller.
Amitriptyline can cause extra side effects if you stop taking it suddenly. Talk to your doctor if you want to stop taking it. Amitriptyline is also used to treat depression, but at lower doses it's very good for treating pain. Check with your doctor before starting to take amitriptyline if you: have ever had an allergic reaction to amitriptyline or any other medicine have a heart problem — amitriptyline can make some heart problems worse have a rare blood disorder called porphyria have liver or kidney problems have epilepsy — amitriptyline can increase seizures or fits have ever taken any medicines for depression — some antidepressants used rarely can affect the way amitriptyline works are pregnant, trying to become pregnant, or breastfeeding have an eye problem called glaucoma — amitriptyline can increase the pressure in your eye have thoughts about harming yourself or ending your life have type 1 or type 2 diabetes If you have diabetes , amitriptyline may change your blood sugar level.
Dosage Amitriptyline tablets come in 3 different strengths — 10mg, 25mg or 50mg. What if I forget to take it? What if I take too much? Urgent advice: Contact for advice now if:. Common side effects Doses of amitriptyline for pain are lower than the doses for depression. Keep taking the medicine but talk to your doctor or pharmacist if these side effects bother you or do not go away: constipation dizziness dry mouth feeling sleepy difficulty peeing headache Serious side effects It happens rarely, but some people have a serious side effect after taking amitriptyline.
Call a doctor straight away if you have: a fast or irregular heartbeat yellow skin, or the whites of your eyes go yellow — these can be signs of a liver problem a headache, feel confused or weak, or get muscle cramps — these can be signs of a low sodium level in your blood thoughts about harming yourself or ending your life eye pain, a change in your eyesight, swelling or redness in or around your eye.
Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction anaphylaxis to amitriptyline. Information: You can report any suspected side effect using the Yellow Card safety scheme.
Visit Yellow Card for further information. What to do about: constipation — eat more high-fibre foods such as fresh fruit and vegetables and cereals. Try to drink several glasses of water or other non-alcoholic drinks every day. If you can, it may also help to do some exercise. Drink plenty of water or other non-alcoholic drinks. Do not stand up too quickly after you have been sitting or lying down. Do not drive, cycle or use tools or machinery if you're feeling this way.
Do not try to force the flow of urine. If you still cannot go, try again later. Talk to your doctor urgently if you cannot pee at all. Do not drink too much alcohol. Try taking paracetamol or ibuprofen if you need pain relief.
Talk to your doctor if the headaches last longer than a week or are severe. Amitriptyline and pregnancy Amitriptyline is generally not recommended in pregnancy. Amitriptyline and breastfeeding Amitriptyline is not usually recommended if you're breastfeeding.
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